Note: E - interfollicular epidermis, DS - dermal sheath of hair follicle.
This experimental system is interesting for us from several points of view:
- It is known that DS cells as well as DP cells in association with ORS cells in vitro don’t produce new HFs. But in vivo this system is capable to induce new HFs.
- DP cells in co-culture with E don’t form HFs, but in vivo they are capable to initiate follicular neogenesis.
Therefore it is interesting, how DS cells will behave in similar conditions?
1. Low-passage DS cells at transplantation into micro-incision of ear skin don’t induce follicular neogenesis.
C. A. JAHODA., F. J. REYNOLDS. Inductive properties of hair follicle cells. // 1991 Annals of the New York academy of sciences . vol 642, p227-242
2. Later these results were once again confirmed in similar experiments by this research group.
REYNOLDS A.J., JAHODA C.A., Hair matrix epidermal cells confer follicle-inducing capabilities on dermal sheath & high passage papilla cells. // Development., vol.122(10)., p.3085-3094., 1996
3. DS fibroblasts and E cells at co-culture in collagen gel form 2 types of structures:
Spheroid bodies with epidermal type of differentiation
Spike-like projectors without no apparent type of terminal differentiation.
JAHODA CA., REYNOLDS AJ ., Dermal- epidermal interaction . Follicle derived cell populations in the study of hair growth mechanism . // J. Invest. Dermatol. 1993 vol. 101 p. 33s-38s |
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