Novel 4-azasteroid, dual 5-alpha reductase (type 1 and 2 isozymes) inhibitor with steroid structure (azasteroid). Not an antiandrogen.
Mechanism:
FCE 27837, reversibly inhibit 5 alpha-reductase in competitive mode, resulting in suppression of serum DHT.
When given orally for 7 days in experimental studies tocastrated and testosterone supplemented rats, FCE 27837 was very effective in reducing prostate growth. At a dose of 0.3 mg/kg/day inhibitions of 41% was caused, reflecting its potenialities.
In other study it reduce prostate DHT by was reduced by 75%, whereas Testosterone content increased by 442%.
No studies on the model of human androgenetic alopecia is known. |
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