Dual 5-alpha reductase inhibitor (type 1 and type 2 isoenzymes).
Mechanism:
CS-891 inhibit both 5alpha-reductase. It lessen both circulating DHT, as well as residual DHT, which is not affected by finasteride.
According to study:
"...Scalp biopsies from healthy volunteers were taken and dermal papillae (DP) were dissected from each biopsy. Groups of six DP were incubated in the presence of 3H-T and CS-891 (at 10 nM, 2 nM, 0.4 nM, 0.1 nM or 0.01 nM) or without treatment for up to 39 hours. Thereafter, HPLC analysis of culture supernatants was performed to detect T-metabolites. Results show that CS-891 is able to block 5aR activity in isolated DP of human HF in a very effective way. Even doses of 0.01 nM CS-891 inhibited 5aR activity in DP by 59%..."
"...This compound may be similarly effective in the prevention or treatment of AGA. Provided the safety profile of CS-891 is proven acceptable, this drug could be effectively used in the treatment of AGA..." |
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